The Thymus Promise
max lifespan
max lifespan
restored
bio years
40
of 600+
Every organ in your body ages. Most do it slowly. The thymus does it fast. By your mid-20s, the thymus — the master gland of your immune system — has already shrunken to a fraction of its peak size. By 60, it's mostly fat tissue. The naïve T cells it once produced, the ones you need to respond to new infections, detect early cancers, and maintain the systemic surveillance that keeps you alive, have stopped coming. This isn't a minor side effect of aging. A growing body of evidence suggests thymus involution is a central cause of it. That raises two questions: can the thymus be regenerated? And if so, what if it never aged at all? We've answered the first question. Intervene Immune is the only company in the world to have pinpointed the exact conditions needed for human thymus regeneration. We hold two broad U.S. patents. Our researchers at the Lundquist Institute have spent a decade building the infrastructure to do this at scale. Now we're answering the second: what if the thymus never aged at all? Thanks to a transgenic mouse model, we can now answer that question directly. This mouse carries a genetic switch that allows continuous, on-demand thymus regeneration — triggered by nothing more than a compound dissolved in drinking water. Regeneration has been confirmed at both 12 and 24 months. The regenerated thymus is structurally and functionally indistinguishable from a young thymus. The Immortal Thymus Project is the first study to use this model for a complete lifespan experiment. If the thymus is what we believe it is — the master regulator of immune aging and much of body-wide aging — this study should produce fantastic results.
The Evidence
The Thymus Controls Far More Than Immunity
A series of landmark studies showed that restoring thymus function reversed aging across multiple organ systems — not just the immune system. Data compiled by Fabris and adapted by Fahy (2010).
Thymus transplantation restored multiple aging biomarkers toward young levels, including brain beta receptor numbers (~80% restoration).
Nature, 1972. Left: 4-month-old untreated Snell-Bagg dwarf mouse showing premature aging. Right: same age, treated — all signs of aging prevented. Which mouse would you rather resemble?
Figure adapted from Fahy, G.M. (2010), based on data compiled by Fabris from five independent studies. Original data sources include Fabris, Pierpaoli, & Sorkin, Nature 240, 557–559 (1972) and others.
Study Design
What We Are Measuring
110 mice in two groups of 55 (treated/untreated, 20 males and 20 females per group for lifespan, 15 per group for assays) — tracked from 2 months through natural death at the Lundquist Institute, Torrance, CA.
Lifespan
Primary endpoint. Goal: surpass the best published lifespan extension results in the literature. Animals tracked through natural death in both groups.
Epigenetic Clocks
Biological age measured at multiple timepoints using standard epigenetic aging clocks — the same methodology that showed reversal in our TRIIM-X human trials.
Immune Profile
Naïve T-cell counts, naïve T-cell function, and immune repertoire diversity — measured at multiple timepoints (every 6–12 months) to confirm ongoing thymic output throughout life.
Thymus Structure
Confirmation of ongoing regeneration throughout the animal's entire lifespan — non-invasive MRI imaging plus histology in sacrificed animals at years 1, 2, 3, and 4.
Senescent Cell Burden
Systemic senescent cell accumulation as a function of immune competence — testing the hypothesis that immune surveillance controls senescence clearance.
Timeline
~4 years to natural endpoint. Year 1 funds: colony establishment, treatment initiation at 2 months (before involution begins), full baseline profiling, and ongoing monitoring.
Campaign
Founding Backer Window — Open Now
Goal: $250,000 to fund Year 1 — limited to the first 100 founding backers
Founding investors have committed to matching every dollar raised during the founding backer window, up to $25,000. Active until the match pool is exhausted. Your pre-order has double the impact.
Milestone Unlocks
Live Q&A with Dr. Greg Fahy for all backers
Quarterly video update from the lab for all backers
Founding backer window closes — exclusive benefits locked in
Pre-Order Tiers
Choose Your Role in History
Every pre-order directly funds the Immortal Thymus lifespan study. Benefits are fulfilled as the program progresses.
Supporter
"You believe the thymus is the missing piece. So do we."
- Name on project page as a founding supporter
- Quarterly email updates & data highlights
- Access to published results & preprints
Pioneer
"Your contribution helps establish the colony in its first critical months."
- All Supporter benefits
- High-quality thymus anatomy art print (shipped after close)
- Early preprint access before public release
Research Partner
"You're funding data that may rewrite what we know about aging — and learning something about your own biology."
- All Pioneer benefits
- Immune status test — clinical assessment of your immune function (pre-order, fulfilled after close)
- Personalized report from the Intervene Immune team
- Named recognition in study documentation
Immortal Circle
Only 20 spots available
"You are building the field."
- All Research Partner benefits
- Exclusive LA event (pre-order)
- Full thymus MRI in Los Angeles (pre-order)
- Personalized full-color 3D rendering of your thymus — physical & digital
- 1:1 consultation with the research team
- Named Founding Patron in study publications
Secure checkout via Stripe. Not a tax-deductible donation.
For Accredited Investors
Equity Investment Opportunity
Intervene Immune is accepting SAFE (Simple Agreement for Future Equity) investments on current terms, with a minimum of $50,000. With the XPRIZE Healthspan Finals approaching in May 2026 and demand for our clinical services already exceeding current capacity, we expect this to be the last opportunity to invest at these terms before we open access more broadly.
Contact Bobby Brooke Directlybrooke@interveneimmune.com • For accredited investors only • Subject to applicable securities laws
The Team
About Intervene Immune
Pioneered the TRIIM protocol — the first clinical demonstration of thymus regeneration in healthy aging adults. Published in Aging Cell and internationally recognized for breakthrough work in immune rejuvenation.
Leads operations, clinical systems, and research systems at Intervene Immune. Oversees the TRIIM-X trial program and the Immortal Thymus Project at the Lundquist Institute, Torrance, California.
Experienced in establishing and maintaining transgenic mouse models. Responsible for day-to-day project execution and troubleshooting for the Immortal Thymus study.
Frequently Asked Questions
A four-year lifespan study at the Lundquist Institute using a transgenic mouse model in which the thymus can be continuously regenerated throughout life. We will track 110 mice in two groups, measuring lifespan, epigenetic aging, immune profile, thymus structure, and senescent cell burden. The primary goal is to produce the most significant longevity finding the field has seen in years — or ever.
It is a pre-order for the benefits listed at each tier. Your payment directly funds the research program and comes with concrete perks — acknowledgments, data access, consultations, and enrollment priority — fulfilled as the program progresses. If you prefer a tax-deductible donation, we can also process contributions through Clock Foundation, a 501(c)(3) nonprofit — contact us at brooke@interveneimmune.com for details.
Quarterly research updates begin after the campaign closes and the study launches. The Pioneer art print ships after the campaign closes. Thymus function assays and personalized reports (Research Partner) are fulfilled after the campaign closes. Immortal Circle MRI imaging and the LA event are scheduled after close — travel to LA at backer's expense. All benefits are fulfilled in good faith over the study's duration.
The $250,000 Year 1 goal covers: transgenic colony establishment, treatment initiation at 2 months, full baseline immune and epigenetic profiling across both groups, and ongoing per diem and monitoring costs through the first treatment year. Research Partners and Founding Investigators receive detailed funding updates.
Yes. Tax-deductible donations to support the Immortal Thymus Project can be made through the Clock Foundation, a 501(c)(3) nonprofit organization. This is especially relevant for larger contributions, corporate giving, and donor-advised funds (DAFs), which require a 501(c)(3) recipient. All tier benefits are still available — the tax-deductible portion is the donation amount minus the estimated fair market value of benefits received. Contact us at brooke@interveneimmune.com to arrange a donation through Clock Foundation.
Join the Mission
We have spent a decade building the science, the team, and the infrastructure to reach this moment. Now is your time to become part of the story of aging control in our time.
Limited to the first 100 founding backers.
Pre-Order NowQuestions? info@interveneimmune.com