The Thymus, Thymus-Mediated Immunity, and the Problem of Thymic Involution
Intervene Immune is dedicated to reversing a process called "thymic involution" in people. Here is why.
The thymus is the master gland of immunity. It is largely responsible, by educating bone marrow-derived cells to become the T cells that carry out cellular immune functions, for protecting you from foreign invaders such as bacteria and viruses, and it is also responsible for attacking tumors. B cells, which are not educated by the thymus, are responsible for "humoral immunity," which is mediated by antibodies. T cells, however, "talk to" B cells and regulate their function, so the thymus has powerful control over most immune functions.
The thymus undergoes an apparently programmed process of atrophy called involution, particularly around the time of puberty, both shrinking and gradually being replaced by fat. This results, finally, in a massive and fairly abrupt collapse of immune system competence sometime between the ages of 65 and 75. Unfortunately, impaired immune system competence is strongly associated with a greatly increased risk of death in humans, both when it happens at younger ages (as in AIDS patients or after irradiation prior to bone marrow transplantation) and when it happens as a result of getting older following thymic involution in youth.
What this means is that, if thymic involution is not corrected, you will eventually die from it, if nothing else kills you first. We believe thymic involution is a major but under-recognized limiting factor for human longevity and health maintenance into old age today, contributing to, for example, the fact that 90% of all flu-related deaths happen in people over the age of 65.
We intend to change this. We believe thymic involution is reversible using techniques that are available today. To prove this, we completed a human clinical trial, the TRIIM trial, to reverse thymic involution in 50-65 year-old normal healthy men. The TRIIM trial is described in more detail at this project page, where you can learn more about it and also make a contribution to help support expansion of the trial.
More Background on Thymus Regeneration
Life Extension Advocacy Foundation: Bobby Brooke - The Potential of Thymus Regeneration
Earlier this year, we hosted the Ending Age-Related Diseases 2018 conference at the Cooper Union, New York City. This was a conference designed to bring together the best in the aging research and biotech investment worlds and saw a range of industry experts sharing their insights...
Life Extension Advocacy Foundation: Dr. Greg Fahy - Rejuvenating the Thymus to Prevent Age-related Diseases
The thymus gland is located at the top of the breastbone and is where the majority of T cells are produced by the immune system. One can think of the thymus as being like an army camp where new soldiers are trained....
Full Article: https://www.leafscience.org/rejuvenating-the-thymus/
Health Extension Salon #14: Greg Fahy Regrew His Thymus
Health Extension Salon yet again lit up my life with wonderment at Hacker Dojo in Mountain View. As usual, there was a great crowd of lively and brilliant attendees...
Can We Restore Thymus Function to Cheat Death?
Dr. Greg Fahy wants to boost our flagging immune systems by rejuvenating our aging thymus and give us a new lease on life, warding off deadly cancer and infections.
There is compelling logic behind Fahy’s idea...