The Thymus, Thymus-Mediated Immunity, and the Problem of Thymic Involution
Intervene Immune is dedicated to reversing a process called "thymic involution" in people. Here is why.
The thymus is considered by many the master gland of immunity. It is largely responsible, by educating bone marrow-derived cells to become the T cells that carry out cellular immune functions, for protecting you from foreign invaders such as bacteria and viruses, and it is also responsible for attacking tumors. B cells, which are not educated by the thymus, are responsible for "humoral immunity," which is mediated by antibodies. T cells, however, "talk to" B cells and regulate their function, so the thymus has powerful control over most immune system functions.
The thymus undergoes an apparently programmed process of atrophy called involution, particularly around the time of puberty, both shrinking and gradually being replaced by fat. This results, finally, in a massive and fairly abrupt collapse of immune system competence sometime between the ages of 65 and 75. Unfortunately, impaired immune system competence is strongly associated with a greatly increased risk of death in humans, both when it happens at younger ages (as in AIDS patients or after irradiation prior to bone marrow transplantation) and when it happens as a result of getting older following thymic involution in youth.
What this research suggests is that, if thymic involution is not corrected, you will eventually die from it, if nothing else kills you first. We believe thymic involution is a major but under-recognized limiting factor for human longevity and health maintenance into old age today, contributing to, for example, the fact that 90% of all flu-related deaths happen in people over the age of 65.
We intend to change this. We believe thymic involution is reversible using techniques that are available today. To prove this, we completed a human clinical trial, the TRIIM trial, to reverse thymic involution in 50-65 year-old normal healthy men.
On Sept. 8, 2019, we published our results from the TRIIM trial. We documented a variety of effects that are consistent with reversing thymic involution, and beyond this, we also demonstrated an unprecedented reversal of epigenetic aging. This amounted to a more than two year increase in predicted human lifespan for the trial volunteers, results based upon the most accurate measures of biological age available today.
The full trial results are published in the journal Aging Cell, and available here: https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13028
More Background on Thymus Regeneration, and the TRIIM Trial Results
Nature: First hint that body’s ‘biological age’ can be reversed
A small clinical study in California has suggested for the first time that it might be possible to reverse the body’s epigenetic clock, which measures a person’s biological age. For one year, nine healthy volunteers took a cocktail of three common drugs...
Full Article: https://www.nature.com/articles/d41586-019-02638-w
Forbes: Cocktail Of Drugs Gives First Hope That ‘Biological Age’ Can Be Reversed
Scientists at Intervene Immune and Stanford Medical Center say they have proven that “epigenetic aging can be reversed in humans.” By testing the blood samples from a clinical trial designed to reverse aspects of human aging, scientists found significant reversal in their epigenetic ages.
Full Article: Link
Science: TRIIM trial to target thymus
The risk of many age-related diseases could be reduced by thymus regeneration to improve immunological protection. In the thymus regeneration, immunorestoration, and insulin mitigation (TRIIM) trial, Fahy et al. developed a method to promote thymus function and reverse immunosenescence...
Full Article: https://science.sciencemag.org/content/366/6468/967.4
Newsweek: Drug trial reverses patients' biological age by an average of more than two years
Scientists believe it may be possible to reverse a person's biological age with a combination of drugs and growth hormones, based on evidence presented in the results of a small clinical study...
Fox News: Study accidentally reveals biological aging may be reversible
A new study shows that scientists might be able to not only slow the process of aging but actually reverse it, Benjamin Button-style...
LiveScience: Could a Drug Cocktail Reverse Biological Aging?
You can't do anything about your chronological age, but it might be possible to turn back the clock on "biological age," a small new study suggests...
Dr. Greg Fahy is interviewed by Lifestyle Expert Linda Cooper
Taking "the science of aging out of the laboratory and into the real world" Host Linda Cooper interviews the elite handful of scientists making a direct impact to reverse the aging process.... Host The interview is of Dr. Greg Fahy, Chief Scientific Officer and Founder of Intervene Immune and his unprecedented reversal of epigenetic aging regenerating immune function...
Full Video: https://vimeo.com/487799045/6bc8312433#
(German) Die Zeit: Forscher wollen das Altern besiegt haben
Ergrauten Männern wachsen wieder dunkle Haare, ihre biologischen Uhren drehen sich rückwärts. Forscher sagen, sie hätten neun Menschen verjüngt. Kann das wahr sein?
(Spanish) La Republica: Científicos logran revertir el envejecimiento por primera vez en la historia
Un grupo de científicos le suministró a nueve personas la hormona de crecimiento en conjunto con otros dos fármacos durante un año. Rejuvenecieron dos años y medio.
Life Extension Advocacy Foundation: Bobby Brooke - The Potential of Thymus Regeneration
The Ending Age-Related Diseases 2018 conference was held at the Cooper Union, New York City. This was a conference designed to bring together the best in the aging research and biotech investment worlds and saw a range of industry experts sharing their insights...
Life Extension Advocacy Foundation: Dr. Greg Fahy - Rejuvenating the Thymus to Prevent Age-related Diseases
The thymus gland is located at the top of the breastbone and is where the majority of T cells are produced by the immune system. One can think of the thymus as being like an army camp where new soldiers are trained....
Full Article: https://www.leafscience.org/rejuvenating-the-thymus/
Health Extension Salon #14: Greg Fahy Regrew His Thymus
Health Extension Salon yet again lit up my life with wonderment at Hacker Dojo in Mountain View. As usual, there was a great crowd of lively and brilliant attendees...
Can We Restore Thymus Function to Cheat Death?
Dr. Greg Fahy wants to boost our flagging immune systems by rejuvenating our aging thymus and give us a new lease on life, warding off deadly cancer and infections.
There is compelling logic behind Fahy’s idea...